Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos
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The article "Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos" is about cancer, it was created by Kirsten Hawkins.
Sarcomatoid Mesotheloima is a quite uncommon type of cancer caused due to asbestos exposure. Whlie it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases.
The possibility of finding that type of cnacer is on the lips and the larynx. However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, that cancer is a fatal disease and hardly responds to any method of traetment.
Even tohugh radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment.
Diagnosis of Sarcomatoid Mesothelioma:
The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis.
Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction betewen it and sarcoma is not always possible.
In that context, the doctors undertook a stduy to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma.
For its study, the researchers stained the mesotheliomas with sarcomatoid componnets. They assesesd the intensity and distribution of staining with the help of a semi quantitative scale. Only tumros with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic proflies of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcritpion factor-1 (TTF-1).
The study shwoed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained.
On the other hand, Calretinin and thrombomodulin each stanied 70% of sarcomatoid.
All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcmoatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings.
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Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos
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